MYELOID NEOPLASIA Expression of the cytoplasmic NPM1 mutant (NPMc ) causes the expansion of hematopoietic cells in zebrafish
نویسندگان
چکیده
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; 2Institute of Hematology, University of Perugia, Perugia, Italy; 3Institute of Cancer, Barts and the London School of Medicine, London, United Kingdom; 4Karlsruhe Institute of Technology, Forschungszentrum Karlsruhe, Karlsruhe, Germany; and 5Division of Hematology/Oncology, Department of Pediatrics, Children’s Hospital, Harvard Medical School, Boston, MA
منابع مشابه
Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.
Mutations in the human nucleophosmin (NPM1) gene are the most frequent genetic alteration in adult acute myeloid leukemias (AMLs) and result in aberrant cytoplasmic translocation of this nucleolar phosphoprotein (NPMc+). However, underlying mechanisms leading to leukemogenesis remain unknown. To address this issue, we took advantage of the zebrafish model organism, which expresses 2 genes ortho...
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تاریخ انتشار 2010